I suggest reading his full quote in the original interview to see what Druckmann really meant: he was focusing on telling that Sony doesn't force ND to make sequels, and instead ND decides to work on what ND wants, depending if they find there's a good story to tell.
After Uncharted 4 they moved to TLOU2 and later to TLOU Online. Sounds they are more interested on a new IP next, and that to have TLOU3 or not would depend if they manage to get a compelling enough story.
Regarding Uncharted, a few months ago both ND studio directors said that they are interested to continue working on Uncharted, TLOU and new IPs. Before that they mentioned they saw Uncharted 4 as the end of Nate's arc.
So probably they continue with a reboot, spinoff, remakes/remasters or simply overview other studio who would lead the next main Uncharted while ND is busy focused on other games (as could be now TLOU MP and a new IP).
Uncharted movie and games have been so successful, so if ND really doesn't want to make more Uncharted, I assume Sony will continue making Uncharted in other studios.
Didn’t they already hand off uncharted? I thought I saw something about that.
In an article where Jason Schreier leaked legit Sony stuff mixed with some lies and FUD later debunked by top Sony devs, he mentioned that after Days Gone, Sony Bend did help ND in the TLOU Online game and started to codevelop an Uncharted spin-off with ND until Bend's next project was greenlighted: the next Bend new IP.
According to Jason Bend was afraid of being absorved by ND, but the Days Gone game directors said it wasn't the case, and that during decades ND and Bend helped each other (in big studios it's common to help other teams between projects).
New IP coming up after factions is pretty much confirmed? It always made no sense that ND was possibly in full development of TLOU part 3 when Druckmann was busy creating the show the last two years. Outside of Rockstar, no developer has as much talent from a technical standpoint as Naughty Dog. I really hope they do something sci-fi or fantasy based for possible new IP
They worked in way more things during these couple of years.
Since the TLOU2 release, in addition to the Uncharted movie and TLOU tv show they worked on the TLOUP1 remake and the Uncharted remasters, plus have been working on their upcoming TLOU MP game. Druckmann also mentioned that he wrote a first draft of what would be the main story of TLOU3 in case they would ever decide to develop it somewhere in the future.
Some hints lead to thing they may also be working on a new IP, and at least until a year or two ago on an Uncharted spinoff at least codeveloped if now almost fully outsourced to Bend (who now is working on something else, so if it wasn't canned it should continue being developed at ND or somewhere else, maybe at Bluepoint).