The overdrive settings on this are much, much better than the super smear ridden XG438Q that it replaced. It's no OLED but at least I can play fast paced fps and not have to willingly ignore the ghosting. A high brightness and 2.2 gamma are helpers for sure.VA panes do smear that is their biggest downside, it takes a lot of work to get an optimal balance were this is minimized (Samsung G7 is one of the better ones). The panels response time could be tuned for 144Hz at the expense of 60hz but seeing as no proper monitor review site (TFT central, PC monitors info, rtings etc) has looked at this monitor to confirm it that is just speculation on my part.
Try and avoid 60hz if possible and keep FPS as high as possible.
Altering the overdrive can improve the response time but it can also cause other visual side effects so its a case of pick your poison.
There is an owners thread over on hardocp for this monitor but I'm not sure there is much else you can do.
Smart has less ghosting than balanced but the reviews say it introduces bad overshoot (inverse ghosting). they haven't seen it on the Asus I had because the fastest on that set was completely unusable. I don't really see it 99.9% of the time.
48 is too big for my desk or I'd have bought a CX for the same price as this ($999 refurb from microcenter). oh, and burn in is basically not a thing if you're half careful but I could be the one to get it with endless hours of Destiny 2's HUD uninterrupted.