Bayonetta and DMC is an obvious one, but would be so. Damned. Good.
Weirder dream option:
Pokemon crossed with Persona.
Fight Shadows with Pokemon and Personas, fuse them into super Personamons, and take down the evil Team Whatever as you unravel a mystery that could end the world, all while juggling school, training, and banging as many of your friends as you can!
The Legend of Zelda: Metroid.
Post Fusion Samus crash lands on an uncharted world after a clash with Space Pirates, immediately ends up in a fight with a late teens The Hero of Time, only for the two to have to team up to take down Gannondorf, whose taken control of the Space Pirates via magic, and intends to use magically resurrected Metroid's to Syphon off the Triforce's power. Switch between the two heroes at any time with an AI partner, or play split screen co-op with a friend!
Lara Croft: Tomb Raider vs Uncharted.
Switching back and forth between Nate and Lara every chapter, slowly unravel the mystery of what the Master Thief stole from Croft Manner, why Lara is so desperate to get it back, and what ancient, world shattering revelation it pertains to, to have caused such a globe trotting adventure.
Jurrasic Park: Isolation.
Alien Isolation, but with Dinosaurs. In to my veins!
Senran Kagura: Summer Lesson.
Because we all have fetishes.
Resident Evil: Fallout.
Fallout, but with a zombie apocalypse rather than nuclear war. Fortified human settlements dotted around an open world crawling with undead and mutations, with all the epic storytelling, great characters, and side quests of Fallout, and campy weirdness, deep lore and horror of Resi. Bliss!