Biggest issues for me so far:
-Constant stuttering when auto-saving or accepting/ completing quests. The original game didn't have that issue on HDDs, I'd expect a fast modern ssd shouldn't stutter like that.
-There's a really annoying bug where the camera constantly focuses and de-focuses on the characters during dialogue trees. Honestly, that's the worst issue for me, too distracting to focus on the actual game.
-Novigrad performance is mediocre, but I don't really expect a fix here. Not terrible on the 60fps mode, but it could use a few improvements.
-The less is said about the RT mode on PS5 the better, it's a mess on too many levels. From performance, to visual artifacts and wrong lighting, you name it. It needs an overhaul to be even worth considering.
-The SSAO without RT is really poor, which is odd considering the game had HBAO way back then so they essentially have downgraded it. Not sure if it's intentional or a bug.