Maybe instead of jumping from a plane you come out of the sewers Ninja Turtles Style?
Have camera somewhat infront of your character running in the dark, a straight line(Cause planes/buss/choppers always go straight?) looking at a touris map; and when choosing to "Exit" you come out the closest hole, with clicking sounds all over seeming like you are beeing chased?
A lot of problems with that, but at least its a start?
As for "Sidekick" like uncharted 4 MP, maybe a dog?
Find them out and about like normal Loot "PVE" style, but befriending them with food and water, and then they could be leshed to your person, helping finding loot or enemies nerby.
Maybe if Infected is PVE the dog's can help you out of a instant death clicker when it grabs you.. dog to the rescue?