Not a fan of more realistic elements as I vastly prefer the more arcade Rockstar games.
But other than that it sounds great, Vice City is still the best setting they've had so I seeing what they can do with it next gen would be amazing.
I doubt they will ever do a modern day GTA again, due to outrage culture and politics (I think Rockstar mentioned this in an interview last year).
Which is fine to me. Bring on the 70's and 80's.
I don't know man, if they are afraid of the Outrage culture I don't know if going to South America is the best move. So many things they could do to be attacked for being "racist", or "enforcing stereotypes" and all of that.
Imagine there being a prominent Cuban character who lives in the US (vice city) and sells drugs, or a depiction of South America where there's a lot of poverty or anything like that, Kotaku and Polygon would have field day with that:
"GTA VI enforces negative stereotypes about immigrants", "The depiction of Cuba/Brazil in GTAVI is problematic", etc