I'm using the Razer Viper, so minimal layout for me. Never been one for a fully decked out mouse, I can't even reach the side buttons on the right side without contracting my fingers in unnatural ways, lol.
I like my wrists they way they are, not full of carpal tunnel, so it's one of these as a driver and a G502 as a gaming mouse.
I HATE pinky drag from mice, trackballs are great, minimal movement from the arm and everything gets done nicely.
I kind of laugh/feel bad about the nerds with the awful mice and "wristbreaker" keyboards, they'll be sorry in about 10-15 years when they look like they've tried to commit suicide from the carpal tunnel surgery scars.
I was using a Logitech g900 but recently bought a Razor Naga Pro. The g900 is small and light, the Naga pro is very much not so. I mostly went with it because it has hot swappable thumb panels, to go from 2, 6, or 12 buttons. I usually use the 6 button one. I really like this idea, but not so much their implementation. The newer versions have a better set up for the 6 button configuration, but I don't want to spent that kind of cash just for that, and I don't know if the thumb panel has the logic to allow it to work on my version if I bought just that, from Ebay or what not.