Its not really lacking any less than other games of similar scale though.
You can say for example its not a very good RPG or the way you affect the story is lacking, but these same things can also be said about The Witcher 3, or Deus Ex games. Its not really much different from those in its shortcomings.
I haven't played it, but people keep saying the city feels dead and empty, and there isn't really much to do in it. That's certainly not something I felt with TW3.
Also the non-existent police AI etc.